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For one bustling Manhattan apartment building, the real day starts after the folks on two legs leave for work and school. That's when the pets of every stripe, fur and feather begin their own nine-to-five routine: hanging out with each other, trading humiliating stories about their owners, or auditioning adorable looks to get better snacks. The building's top dog, Max, a quick-witted terrier rescue who's convinced he sits at the center of his owner's universe, finds his pampered life rocked when she brings home Duke, a sloppy, massive mess of a mongrel with zero interpersonal skills. When this reluctant canine duo finds themselves out on the mean streets of New York, they have to set aside their differences and unite against a fluffy-yet-cunning bunny named Snowball, who's building an army of Ex-Pets abandoned by their owners and out to turn the tables on humanity all before dinnertime.