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In rural Maine, Vic and Donna Trenton struggle to repair their crumbling marriage, while their young son Tad befriends a hulking, lovable, 200-pound St. Bernard named Cujo. With Vic away on business, Donna and Tad take their decrepit car to be fixed at their mechanic's remote farm. As their aging Pinto sputters to a stop and dies, Cujo appears. But the once docile dog has undergone a hideous transformation - and becomes a slavering, demonic, impeccable killer possessed of almost supernatural strength...and unholy cunning.