Gus and Joe live to fish. Since their boyhoods in Newark, New Jersey, they have spent day after day on the dock praying to catch "The Big One"--but with no success. After winning Bait & Tackle's grand prize vacation package for their essay on "How Come We Fish...," the bosom buddies set out for the adventure they have always dreamed of in the plentiful Florida Everglades. On the road to the Glory Glades Lodge in a '68 Plymouth Barracuda--towing their modest fishing boat--Gus and Joe stumble into trouble when they meet the sinister and cunning Dekker Massey, who is on his way to dig up $2.5 million of stashed cash and jewels stolen from his ex-wives. Massey steals Gus and Joe's car, leaving them stranded with their boat and trailer. The twosome hitch a ride with Rita and Angie, who are also after Massey and the stolen goods. Chaos and havoc turn Joe and Gus' much-anticipated fishing retreat into a comedic run for their lives.