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It's been exactly 20 years since we left Lloyd and Harry playing tag, and everything but their idiocy has changed. When the new-kidney-needing Harry learns that he has a daughter out there, he must snap Lloyd out of the "comatose" state he's been in since Mary's rejection and hit the road to request her help. Crisscrossing the country in insane transportation, their journey to find her will take them from a mental institution-where they belong-to a summit that is playing host to the world's most brilliant minds. Well, not anymore.