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Five strangers awaken to find themselves trapped aboard an alien mothership that seems to be harnessing their terror and emotions to power the ship. They begin to understand that this alien species has been abducting humans for decades and possibly centuries. Among the group is Sera, a young woman who is actually a human-alien hybrid sent to the ship by the U.S. military in a plan known as Project Ithaca to destroy the mothership. After the grisly murder of one of their fellow prisoners, the group must learn to work together to escape and find a way home.