In 1954, on a fortress-like island housing a hospital for the criminally insane at the height of the Cold War, U.S. Marshal Teddy Daniels and his new partner, Chuck Aule, are summoned to Shutter Island to investigate the implausible disappearance of a brilliant multiple murderess from a locked room within the impenetrable Ashecliffe Hospital. Surrounded by probing psychiatrists and dangerously psychopathic patients on the remote, windswept isle, they arrive into an eerie, volatile atmosphere that suggests nothing is quite what it seems. With a hurricane bearing down on them, the investigation moves rapidly. Yet, as the storm escalates, the suspicions and mysteries multiply. There are hints and rumors of dark conspiracies, sordid medical experiments, repressive mind control, secret wards, perhaps even a hint of the supernatural, but elusive proof. Moving in the shadows of a hospital haunted by the terrible deeds of its slippery inhabitants and the unknown agendas of its equally ingenious doctors, Teddy begins to sense that the deeper he pursues the investigation, the more he will be forced to confront some of his most profound and devastating fears. And he realizes that he may never leave the island alive.