Some of the ghouls from Monster High (Lagoona, Cleo, Clawdeen, Draculaura and Frankie, Abbey and Ghoulia) go on a cruise to the Great Barrier Reef, but their ship sinks during the trip. Luckily, Mr. Farnum rescues them, and agrees to take them to the Great Barrier Reef. But he tricks them and they end up in Skull Shores, a place where a monstrous beast fears the locals. The girls find out that the beast is not what it looks like and they decide to welcome him among them. Together, they now have to come up with a plan to Escape from Skull Shores, as Farnum still plans to kill the beast and anyone that stays on his path.