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Ever since hulking lawman Hobbs, a loyal agent of America's Diplomatic Security Service, and lawless outcast Shaw, a former British military elite operative, first faced off, the duo have swapped smack talk and body blows as they’ve tried to take each other down. But when cyber-genetically enhanced anarchist Brixton gains control of an insidious bio-threat that could alter humanity forever — and bests a brilliant and fearless rogue MI6 agent, who just happens to be Shaw’s sister — these two sworn enemies will have to partner up to bring down the only guy who might be badder than themselves.